Abstract
Peculiarities of the combined effects of acetylcholine (ACh) and serotonin (St) on the pattern of histamine (His)-induced gastric secretion were studied on intact rats and rats with gastric impairments. Destructive and hemorrhagic changes of the gastric mucosa were modeled by i.p. injections of noradrenaline. The gastric secretory function was estimated using a perfusion technique. It was shown that the above stressor influence resulted in impairment of 20–60% of the gastric mucosa surface. Combined action of ACh, St, and His in intact animals revealed a dominating effect of St on acid secretion. Acetylcholine and St modulated the secretory activity of main cells, but their combination exerted no clear effect on pepsinogen secretion. Serotonin, if used against the background of His injection, restrained acid and pepsin secretions. In the animals with structural and hemorrhage disturbances of the gastric mucosa, the secretion indices characterazing combined action of the neurotransmitters decreased.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
