Combined effects of DL-?-aminoadipic acid with sodium iodate, ethyl alcohol, or light stimulation on the ERG c-wave and on the standing potential of albino rabbit eyes

Abstract

Albino rabbits were treated with intravitreal injections of DL-alpha-aminoadipic acid (alpha-AAA) into one eye (0.1 ml of a 0.15 M solution) and 0.1 ml of saline into the contralateral eye. Thirteen to fourteen hours later the DC electroretinogram (ERG) and/or the standing potential (SP) were recorded. (1) In eight of nine animals the c-wave amplitude of alpha-AAA injected eyes was increased compared with that of control eyes. Following intravenous injection of Sodium Iodate (40 mg/kg in 2% solution) the c-waves of both eyes were rapidly replaced by negative potentials. In 8 of 9 animals the amplitude reduction was more marked in alpha-AAA-treated eyes than in control eyes, but the final amplitude was higher in the former than in the latter. The SP was reduced with difference in curve form but not significantly in amplitude between the eyes. (2) In nine other rabbits iv.-injected ethyl alcohol (0.4 g/kg in 20% solution) provoked a transient increase of SP level and c-wave amplitude in control eyes and smaller but similar changes in alpha-AAA injected eyes. (3) In another five animals the SP was recorded following a step from darkness to continuous light stimulation. The light peak was less pronounced in alpha-AAA treated eyes than in control eyes.