Combined effect of celecoxib and glucosamine sulfate on inflammatory factors and oxidative stress indicators in patients with knee osteoarthritis

Deng Gang,Yang Kanghua,Chen Xiaguang,Wu Aiping,Zeng Guangxuan

doi:10.4314/tjpr.v18i2.25

Abstract

Purpose: To investigate the combined effect of celecoxib and glucosamine sulfate on inflammatory factors and oxidative stress indicators in patients with knee osteoarthritis (KOA). Methods: Patients were randomly assigned to two groups of 60 patients each: control group and study group. The control group received celecoxib at a dose of 200 mg/kg/day, while the study group received glucosamine sulfate (500 mg/kg) in addition to celecoxib, thrice a day. Treatment in both groups lasted 8 weeks. The serum levels of tumor necrosis factor α (TNF-α), interleukin-1 (IL-1), prostaglandin-2 (PGE2), malondialdehyde (MDA), and activity of superoxide dismutase (SOD) were assayed before and after treatment. Visual analogue scale (VAS), osteoarthritis index, Lysholm knee score scale (LKSS), and adverse reactions were also evaluated. Results: After treatment, total effectiveness was significantly higher in the study group (91.33 %) than in control group (71.67 %, p < 0.05). Serum TNF-α, IL-1 and PGE2 were significantly lesser in the glucosamine sulfate-treated patients than in control group ( p < 0.05). The activity of SOD was significantly higher in glucosamine sulfate-exposed patients than control patients ( p < 0.05). On the other hand, VAS and WOMAC scores were markedly lower in patients given glucosamine sulfate than in control patients ( p < 0.05). Conclusion: The combination of celecoxib with glucosamine sulfate effectively reduces immune inflammatory response, oxidative stress damage, and joint pain associated with KOA. Keywords: Celecoxib, Glucosamine sulfate, Osteoarthritis, Inflammatory factors, Oxidative stress

Highlights

Osteoarthritis (OA) is a degenerative disease of bones and joints which occurs mainly in the knee joint, hip joint, spine and other parts in middleaged and elderly people
Joint fluid was taken before and post-treatment, and tumor necrosis factor α (TNF-α), IL-1 and PGE2 were assayed in serum using ELISA kits
This is due to the release of huge amounts of IL-1 and TNF-α in the synovial fluid as a result of phagocytic degradation of synovial cells, which adversely affects the metabolism of chondrocytes [7,8]

Summary

INTRODUCTION

Osteoarthritis (OA) is a degenerative disease of bones and joints which occurs mainly in the knee joint, hip joint, spine and other parts in middleaged and elderly people. It is caused by pain and joint dysfunction. -©---2-0--1--9---T--h-e---a--u-t-h--o-r-s--.--T-h--i-s--w--o--r-k--i-s--l-i-c-e--n-s--e--d--u--n--d-e--r--t-h-e---C--r-e--a-t-i-v-e---C--o--m-T-m-r-o-o-pn--sJ--AP--th-t-ra-i-br-mu--t-iRo--ne--s-4,-.-F0--e-Ibn--rt-eu--ra-n-ra-y-t-i2o--0n--1a-9l--;L--i1c--8e-(n-2-s-)-e:--3--9-7 synthesis of prostaglandins by inhibiting cyclooxygenase-2 (COX-2) It can effectively relieve pain, but cannot effectively prevent longterm recurrence of the disease [2]. Glucosamine sulfate, a naturally occurring amino sugar in the matrix of cartilage, effectively repairs damaged soft tissue and inhibits the recurrence of inflammation [3]. Previous studies have shown that a combination of celecoxib with glucosamine sulfate could effectively control inflammatory response and reduce its long-term recurrence [4]. Parameter Gender (male/female) Age (years) Course of disease (years) Condition - Mild Condition - Moderate Condition - Severe

METHODS

Evaluation of oxidative status

DISCUSSION

Limitations of the study

Conflict of Interest