Combined Doppler ultrasound and platelet indices for prediction of preeclampsia in high-risk pregnancies

Abstract

Objectives: To evaluate Doppler ultrasound and platelet indices for the prediction of preeclampsia (PE). Design: Prospective observational study. Methods: The study included 270 normal pregnancy primigravida <20 years at 20–24-week gestation. Doppler ultrasound was done to detect uterine artery diastolic notch and to measure the pulsation index (PI) and the resistance index (RI). The platelet count (PC), mean platelet volume (MPV), platelet distribution width (PDW) and platelet large cell ratio (Plcr) was measured by automated blood picture. Outcome: Validity of combined tests in prediction of PE. Results: Patients who developed PE had significant higher percentage of diastolic notch, higher mean PI, RI, and significant increase of MPV and PDW than normotensive women (p < .001). Patients with abnormal Doppler and abnormal platelet indices had significant higher incidence of severe PE (p < .001). Conclusion: Abnormal platelet indices combined with abnormal Doppler is a predictor of severity rather than the rate of development of PE.