Combined Dexamethazone/Chlorpheniramine Mouth Rinse Effect on Candida Albicans and sIgA in Patients with Recurrent Aphthous Ulceration

Abstract

Aim of study: Determine the level of salivary candida albicans and secrotory Immunoglobulin A (sIgA) before and after combined Dexamethasone/chlorphinramine mouth rinse use. 65 patients with RAS were selected and divided randomly into 2 groups, study group consist of 45 patient informed to use the combined dexamethasone/chlorphineramine mouth rinse 4 timed a day for 10 days, and control group consist of 20 patients without mouth rinse. Candida albicans (colony forming unit/ml) and sIgA were measured at starting and after 10 days for all patients. The results showed that there is a significant increase in the number of candida albicans in study group (p value is 0.028) while in control group there is no significant difference in candida albicans (p value is 0.772). sIgA results showed no significant difference neither in study group (p value is 0.598) nor in control group (p value is 0.744). Despite these results there was no clinical adverse reaction observed regarding oral candidasis. Combined Dexamethasone/chlorphinramine mouth rinse is safe to use in treating RAS lesions for 10 days without the need for antifungal drug to be added to the combination.