Abstract
BackgroundIn China, few studies have examined the relationship between the combination of body mass index and waist circumference and the risk of stroke. Moreover, the relationship may also be different in different genders. Thus, we investigated the association between the combination of body mass index and waist circumference and the risk of stroke in Chinese.MethodsThis prospective cohort study included 36 632 participants aged 18 to 90 years. Participants were recruited from 60 surveillance sites (25 urban sites and 35 rural sites) across China in 2010 China Chronic Disease Risk Factor Surveillance, and followed up in 2016-2017. Incident cases of stroke were identified through questionnaires (including the basis of clinical diagnosis, imaging tests, time of diagnosis, diagnosis unit) and Cardiovascular Event Report System. Risk factors for stroke were collected at baseline using questionnaire, physical measurements and laboratory tests. Cox proportional hazards regression models were used to generate adjusted hazard ratios and 95%CI. All analyses were duplicated by gender stratification.ResultsDuring 6.42 ± 0.50 years of follow-up, 1 333 (597 males, 736 females) stroke events were observed among the 27 112 participants who did not have cardiovascular diseases at baseline. Compared with the general population who have normal weight or underweight with normal WC, those who have normal weight or underweight with abdominal obesity (adjusted hazard ratios 1.45, 95%CI 1.07-1.97 in males; 0.98, 95%CI 0.78-1.24 in females), overweight with abdominal obesity (1.41, 95%CI 1.14-1.75 in males; 1.33, 95%CI 1.10-1.61 in females), obesity with abdominal obesity (1.46, 95%CI 1.11-1.91 in males; 1.46, 95%CI 1.17-1.81 in females). Overweight with normal WC was found to be not statistically significant for both males and females (all P>0.05). Subgroup analysis found a multiplicative interaction between age and anthropometric group in females (P for interaction <0.05). Sensitivity analysis results did not change. In the subjects with CVD risk factors, we found a similar relationship as in the general population .ConclusionsCombined assessment of body mass index and waist circumference identifies obesity patterns associated with stroke risk.
Highlights
In China, few studies have examined the relationship between the combination of body mass index and waist circumference and the risk of stroke
Study design and baseline survey This study is a prospective cohort study to investigate the association between the combination of body mass index and waist circumference and the risk of stroke in Chinese
In male with baseline hypertension, diabetes, low high-density lipoprotein cholesterol (HDL-C), or CVD risk factors, we found that stroke risk remained increased in the normal weight or underweight/abdominal obesity, overweight/abdominal obesity, and obesity/abdominal obesity groups
Summary
In China, few studies have examined the relationship between the combination of body mass index and waist circumference and the risk of stroke. We investigated the association between the combination of body mass index and waist circumference and the risk of stroke in Chinese. The number of stroke patients is about 13 million, and the age-standardized prevalence, incidence, and mortality rates of stroke were 11.2/1000 people, 2.5 and 1.2/1000 person-years, respectively [6, 7]. Such a heavy disease burden of stroke has been of great concern. Identifying and modifying risk factors is essential for controlling the epidemic of stroke
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.