Combined concurrent nanoshell loaded macrophage-mediated photothermal and photodynamic therapies

Henry Hirschberg,Anthony Trinidad,Qian Peng,Catherine Christie ,Young Jik Kwon ,Steen J Madsen

doi:10.1117/12.2082850

Combined concurrent nanoshell loaded macrophage-mediated photothermal and photodynamic therapies

Henry Hirschberg, Anthony Trinidad + Show 4 more

https://doi.org/10.1117/12.2082850

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Publication Date: Feb 26, 2015

Citations: 5

Affiliation: University of Nevada, Las Vegas, Beckman Laser Institute and Medical Clinic, Oslo University Hospital, University of California, Irvine

#Head And Neck Squamous Cell Carcinoma #Use Of Macrophages + Show 8 more

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Abstract

Macrophages loaded with gold nanoshells (AuNS), that convert near infrared light to heat, can be used as transport vectors for photothermal hyperthermia of tumors. The purpose of this study was to investigate the effects of combined macrophage mediated photothermal therapy (PTT) and PDT on head and neck squamous cell carcinoma (HNSCC). The results provide proof of concept for the use of macrophages as a delivery vector of AuNS for photothermal enhancement of the effects of PDT on squamous cell carcinoma. A significant synergy was demonstrated with combined PDT and PTT compared to each modality applied separately.

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