Combined application of microneedling and laser therapy in the correction of involutive changes

Abstract

The relevance of research. In the XX–XXI centuries, the average life expectancy has increased significantly and the issues of not only maintaining health, but also the appearance have acquired social significance. The aging of the skin as an organ is different as it combines intrinsic aging and extrinsic aging, which is limited to environmentally exposed skin such as the face, back of the hands and neck. Therefore, the development of new methods for correcting involutive changes, taking into account the clinical symptoms of natural aging and photodamage, is relevant. Material and methods. Under observation were 82 patients aged 40 to 50 years. Patients were divided into 3 groups depending on the therapy. All patients underwent enzyme immunoassay to determine MMP-2, MMP-3, MMP-12, TGFβ2 before and after treatment. Research results. In patients with involutive changes, to a greater extent, when combined with signs of photoaging, the content of matrix metalloproteinases (MMP-2, MMP-3, MMP-12) and transforming growth factor beta (TGFβ2) in the skin is increased. The combined use of microneedling and Er:YAG laser to a greater extent than the use of the components of the method reduces the content of matrix metalloproteinases (MMP-2, MMP-3, MMP-12) and transforming growth factor beta (TGFβ2) in the skin.