Abstract
ABSTRACTThe combined virus-inhibitory effects of a proteinaceous protease inhibitor, produced by Streptomyces sp. 225b (BF), rimantadine hydrochloride (Rim), ε-aminocaproic acid (ACA) and a polyphenol extract from Geranium sanguineum L. (PC) have been investigated on the reproduction of influenza virus A/Germany/34, strain Rostock (H7N1) in MDCK cell cultures. The simultaneous application of BF and PC, a plant preparation with established anti-influenza-virus activity, led to antagonistic virus-inhibitory effect. The combined use of BF and Rim, a selective anti-influenza drug, in doses, which by themselves do not suppress significantly viral replication, resulted in an additive increase of inhibition. The combinations BF+ACA, both of the preparations being proteolytic inhibitors, limited viral replication in a synergistic fashion. The results support the efficacy of combined chemotherapy; however to achieve a synergistic enhancement of the virus-inhibitory effect it is essential to precisely select the doses of the individual components in the combinations.
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