Abstract
Combinatorial treatment of curcumin or silibinin with doxorubicin sensitises high-risk neuroblastoma
Highlights
Neuroblastoma is the most common extracranial solid tumour that occurs in childhood[1]
The combinatorial therapy significantly reduced the tumor burden and increased the survival of mice implanted with high-risk neuroblastoma cells
Taken together, this study shows the efficacy of using curcumin in combination with doxorubicin to improve the survival rate and has the potential to enhance the quality of life of neuroblastoma patients
Summary
Neuroblastoma is the most common extracranial solid tumour that occurs in childhood[1]. The clinical behaviour of this complex disease is highly diverse, ranging from a benign tumour mass with no symptoms to a progressive and fatal disease with resistance to current treatments[2,3]. This aggressive cancer is the most common cancer diagnosed during the first two years of human life[4]. The Children’s Oncology Group has developed a risk group stratification system in order to categorise the treatment strategies[13] This system is mainly based on the stage of the disease, amplification status of N-Myc, DNA index and histopathology
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