Abstract

Re ligands. The combinatorial assembly of independent modules A and B through oxorhenium(V) coordination was investigated, and the oxorhenium complexes A⋅ReVO⋅B were evaluated as novel ligands of cyclophilin hCyp-18. Two rhenium complexes that bind to hCyp-18 with an affinity more than one order of magnitude higher than that of the corresponding modules were selected from two libraries (288 rhenium complexes).

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