Abstract
Here we describe a revolutionary method for the rapid selection of monoclonal antibodies. A phagemid system for the monovalent display of combinatorial Fab libraries on the surface of filamentous phage M13 was developed. Phage displaying Fab fragments on their surface (Phabs) were enriched on antigencoated surfaces 10 3 - to 10 5 -fold over nonspecific phage. This method provides the most expeditious route to monoclonal antibodies yet described.
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