Abstract
A significant drop of blood lipids (P<0.01), IMT(P<0.01), area of Carotid intima of atherosclerotic plaque(P<0.01), PAPP-A(P<0.01) and hs-CRP( P<0.01) were observed in atorvastatin+ probucol group. All parameters were improved significantly comparing with atorvastatin alone. Neurological deficit scores of these two groups had significantly different after treatment (P<0.01). Combination therapy had better efficacy. The correlation analysis showed that seriousness of ischemic stroke on admission day and 1 month of treatment was associated with the hsCRP levels significantly. Conclusion Short-term use of atorvastatin combining with probucol could have a significant effect on ischemic stroke in clinic.
Highlights
Atorvastatin combined with probucol was considered in theory to be effects in treating ischemic stroke and preventing recurrent
All parameters were improved significantly comparing with atorvastatin alone
Neurological deficit scores of these two groups had significantly different after treatment (P
Summary
Atorvastatin combined with probucol was considered in theory to be effects in treating ischemic stroke and preventing recurrent. The clinic data about it were very few, so we observed the effects of atorvastatin and probucol in combination in the patients with ischemic stroke
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