Abstract
Antihypertensive treatment is associated with risk reduction of cardiovascular events like coronary heart disease, heart failure, stroke and renal events. Monotherapy is indicated in the treatment algorithm especially for grade 1 or mild hypertension. In the vast majority of hypertensive patients, effective BP control can only be achieved by combination of at least two antihypertensive drugs. Combination antihypertensive therapy is recommended in recent guidelines as a potential first-line therapy in patients with high baseline blood pressure and high cardiovascular risk. The combination therapy consisting of ACE inhibitor and diuretic or ACE inhibitor and calcium antagonist are recommended and effective drug combinations in major clinical trials.
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