Abstract
Increasing appreciation of the complexity of the wet type of age-related macular degeneration (AMD) has made combination therapy an area of current intense interest. Administered in dual or triple combinations, the current therapeutic mainstays ߝ corticosteroids, verteporfin photodynamic therapy (V-PDT) and inhibitors of vascular endothelial growth factor (VEGF) ߝ have more potential to successfully treat the various pathogenetic factors contributing to wet AMD than any single-therapy approach. The different mechanisms of action involved in combination therapy are intended to reduce inflammation, eradicate current and future choroidal neovascularisation and lessen VEGF expression. Evidence from clinical trials demonstrates visual acuity benefits, lower re-treatment rates and longer treatment-free intervals with combination therapies compared with monotherapies. This article summarises the rationale and the clinical evidence that support the use of double and triple combination therapy in wet AMD.
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