Abstract
We investigated the activity and toxicity of a combination of vinorelbine 25 mg/m 2 on days 1 and 15; epirubicin 25 mg/m 2 on days 1, 8, 15; and 5-fluorouracil continuous infusion at 200 mg/m 2 every day, administered as first-line chemotherapy in anthracycline-naïve metastatic breast cancer patients. Fifty-three patients entered the study. Cycles were repeated every 28 days. Objective response was 60% by World Health Organisation (WHO) criteria and 63% by Response Evaluation Criteria in Solid Tumours (RECIST). The median time to progression was 12.7 months (17.6 months in responders) and the median survival duration was 32.9 months. The dose-limiting toxicity was leucopenia (grade 3/4 in 36% of patients). Grade 3/4 non-haematological toxicities included mucositis in 11% of patients, skin and cardiac toxicity in 4% and 2%, respectively. The combination of vinorelbine, epirubicin and 5-fluorouracil continuous infusion was found to be an active and manageable first-line regimen for metastatic breast cancer patients.
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