Abstract
Stilbenes are a major grapevine class of phenolic compounds, known for their biological activities, including anti-inflammatory and antioxidant, but never studied in combination. We aimed to evaluate the effect of trans-resveratrol + ε-viniferin as an antioxidant mixture and its role in inflammatory development an in vivo model of severe acute liver failure induced with TAA. Trans-resveratrol + trans-ε-viniferin (5 mg/kg each) was administered to Wistar rats. Resveratrol + ε-viniferin significantly decreased TBARS and SOD activity and restored CAT and GST activities in the treated group. This stilbene combination reduced the expression of TNFα, iNOS, and COX-2, and inhibited MMP-9. The combination of resveratrol + ε-viniferin had a hepatoprotective effect, reducing DNA damage, exhibiting a protective role on the antioxidant pathway by altering SOD, CAT, and GST activities; by downregulating TNFα, COX-2, and iNOS; and upregulating IL-10. Our results suggested that adding viniferin to resveratrol may be more effective in hepatoprotection than resveratrol alone, opening a new perspective on using this stilbene combination in functional diets.
Highlights
The search for possible plant metabolites to develop novel food components with improved health-promoting properties is gaining interest among both the scientific community and the food industry [1]
The present study aimed to evaluate the effect of a combination of trans-resveratrol and ε-viniferin on the oxidative stress and inflammatory process in an in vivo model of SALF induced by thioacetamide (TAA), and infer its nutraceutical or dietary potential to liver injury
SALF syndrome causes a noticeable decline of hepatic function, leading to multiple organ failure, which is related to a high mortality rate
Summary
The search for possible plant metabolites to develop novel food components with improved health-promoting properties is gaining interest among both the scientific community and the food industry [1]. Stilbenes are a major class of phenolic compounds present in grapevine. Emerging in vitro and in vivo studies corroborate that trans-resveratrol exhibits therapeutic effects on some liver disorders, leading to, for example, a significant increase in survival rates after liver transplantation, as well as a decrease in fat deposition, necrosis, and apoptosis. It provides liver protection against chemical, cholestatic, Nutrients 2021, 13, 3677 in survival rates after liver transplantation, as well as a decrease in fat deposition, necrosis, and apoptosis. Theheanatniptirporloifleifre-rative ative aannddpprrooaappoopptototitciceefffefectcstsoof ftrtarnasn-sr-ersevsevreartartorloalnadnditsitosloigliogmomerse,risn, cinlucdluindginεg-vεi-nviifneirfienr,in, on on HeHpGep2Gca2nccaenrcceerllcsealnlsdahnudmhaunmcaonlocnocloanccearncceellrscheallvsehaalsvoe baelseon bperenviopuresvlyiosuusglgyessutegdgested with iswoiltahteidsoclaotmedpocoumndpso[u5n].ds [5]
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