Abstract
A novel polycaprolactone (PCL) bearing sulfobetaine (SB) and N,N-dimethylamine (DMA) pendent groups distributed randomly along the biodegradable PCL backbone, P(SBCL-co-DMACL-co-CL), PSDCC was synthesized by combination of ring-opening polymerization and ‘‘click’’ chemistry. The chemical composition and the structure of PSDCC were confirmed by 1H nuclear magnetic resonance (1H NMR) spectroscopy, fourier transform infrared (FT-IR) spectroscopy and gel permeation chromatography (GPC). Studies on the self-assembly in water show that the PSDCC nanoparticles have a narrow size distribution with the diameter about 140 nm. Besides, the nanoparticles possess enhanced stability, pH-sensitive doxorubicin (DOX) release behavior, excellent biocompatibility and cellular uptake to MCF-7 cells. Therefore, the copolymer of PSDCC synthesized by this simple method is a highly promising material as a new drug delivery carrier for cancer therapy.
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