Abstract
Three groups of 6–8 week old male C 57 B1 6 × DBA2 F1 mice with transplanted Lewis tumour were irradiated by a single dose of Cobalt 60 localized on the tumour in association with intraperitoneal injections of BCG. When the animals were sacrificed, tumour parameters were determined: weight, surface area, volume and lung metastasis. When BCG was applied up to and including the 4th day following the end of the irradiation, tumour growth and the number of lung metastases were significantly decreased in comparison with the control group (P < 0·01). In all the groups where BCG treatment was started after the 4th day post-irradiation, there was no effect of BCG when compared with radiotherapy alone. This emphasizes the importance of timing in radiotherapy and immunotherapy association.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
