Abstract
The bronchodilator effect of a combination of 200 μg salbutamol and 200 μg oxitropium bromide, given as pressurized aerosols, was compared to that of 200 and 400 μg of salbutamol in a controlled experiment on adult patients with asthma. The combined and the high dose salbutamol treatments were equally effective with respect to the response measured 60 minutes after administration, and both were significantly superior to the low dose salbutamol treatment. Bronchodilation persisted longer following the combined treatment than following the low or high dose salbutamol treatment. The results suggest that enhancement of the early bronchodilator response obtained by adding oxitropium bromide to a conventional dose of salbutamol in patients with stable asthma reflects suboptimal dosing of salbutamol rather than differences between the agents in mechanisms of action, whereas enhancement in duration of response is related also to the pharmacological characteristics of oxitropium bromide.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
