Abstract
Cell-based drug delivery systems have shown tremendous advantages in cancer treatment due to their distinctive properties. For instance, delivery of therapeutics using tumor-tropic cells like neutrophils, lymphocytes and mesenchymal stem cells can achieve specific tumor targeting due to the “Trojan Horse” effect. Other circulatory cells like erythrocytes and platelets can greatly improve the circulation time of nanoparticles due to their innate long circulation property. Adipocytes, especially cancer-associated adipocytes, play key roles in tumor development and metabolism, therefore, adipocytes are regarded as promising bio-derived nanoplatforms for anticancer targeted drug delivery. Nanomaterials are important participants in cell-based drug delivery because of their unique physicochemical characteristics. Therefore, the integration of various nanomaterials with different cell types will endow the constructed delivery systems with many attractive properties due to the merits of both. In this review, a number of strategies based on nanomaterial-involved cell-mediated drug delivery systems for cancer treatment will be summarized. This review discusses how nanomaterials can be a benefit to cell-based therapies and how cell-derived carriers overcome the limitations of nanomaterials, which highlights recent advancements and specific biomedical applications based on nanomaterial-mediated, cell-based drug delivery systems.
Highlights
Recent decades have witnessed the tremendous progress of nanobiotechnology in cancer treatment [1,2]
Thetumors varietyand of long circulation time developing in vivo afterresearch systemicarea injection, tropism towards cell types and the diversity of cell surface conjugation chemistries provide more possibilinflammatory sites
Order to supportorthe metabolism of tumorDDSs cells, with lipid ities for exploring a wide range ofInNP-encapsulated nanomaterial-decorated droplets can accumulate during the lipolysis process triggered by tumor cells, which can be used as a “Trojan horse” strategy for local and sustained delivery of different drugs at the tumor sites
Summary
Recent decades have witnessed the tremendous progress of nanobiotechnology in cancer treatment [1,2]. Cell-mediated drug delivery has become a promising approach in addressing the aforementioned limitations This innovative strategy takes advantage of the natural properties of various cells such as prolonged circulation time in blood stream, specific targetability to tumor cells, the ability to cross challenging biological barriers, abundant surface ligands, flexible morphology, and cellular signaling or metabolism [21]. Different cell types possess distinctive properties, which enables their multifunctional application in personalized cancer treatment It is discussed how nanomaterials empower the field of cell-based treatment and how cellular characteristics improve the performance of nanomedicine.
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