Abstract
The design and fabrication of porous scaffold remains a major challenge in bone tissue engineering. Hierarchical microporous and macroporous structures in scaffold contribute different biological functions to tissue regeneration. This study introduced an integrated manufacturing method to fabricate hierarchical porous polymer scaffolds. Firstly, polylactic acid (PLA) scaffolds with 100–800μm macropores were fabricated by applying fused deposition modeling (FDM) techniques. Then, 1–10μm micropores were generated in scaffolds through gas foaming. This combined technique avoids the disadvantages of pure 3DP or gas foaming technology and elicits positive cooperative effects to fabricate hierarchical porous scaffolds. The design of porosity in scaffold could offer innovative opportunities to control cell performance within 3D microenvironments.
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