Abstract
In this paper, five different nano-platforms were synthesized by combining different ratios of cobalt, manganese, and iron to obtain an efficient photosensitizer for the treatment of breast cancer. Bovine serum albumin was used as a bio coating agent to improve the biocompatibility of the prepared nano-platforms. Moreover, curcumin as an herbal anticancer agent was attached to albumin by a hydrazone pH-sensitive linker to improve the efficiency of drug delivery and obtain the synergistic effect of photodynamic therapy and chemotherapy. Different analysis methods including X-ray diffractometer, energy dispersive X-ray, ultraviolet–visible spectroscopy, field emission-scanning electron microscopy, Fourier-transform infrared spectroscopy, vibrating sample magnetometer, and thermogravimetric analysis were used to characterize the synthesized photosensitizers. After the identification and initial evaluation of their in vitro and in vivo properties, Co 0.5 was selected to be coated with bovine serum albumin to improve its biocompatibility, and the related tests confirm this fact. Further studies revealed that the cell viability of curcumin-loaded bovine serum loaded @ nano-platforms decreased to 40% in the presence of visible light at the concentration of 1000 µg/mL. These results can prove the great potential of bovine serum albumin and curcumin to improve the photodynamic performance of nano-platforms.
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