Abstract
Insomnia is often ignored in the diagnosis and treatment of patients of stroke. The present study aimed to evaluate the efficacy of alprazolam (ALP) combined with Bailemian capsule (BC, a traditional Chinese patent medicine) in the treatment of post-stroke insomnia (PSI). A total of 231 stroke patients involved in this retrospective study were treated with ALP, BC, or ALP + BC for 3 weeks. The quality of sleep was evaluated by the Pittsburgh Sleep Quality Index (PSQI) and polysomnography (PSG), while self-care ability was monitored by the modified Rankin Scale (mRS) before and after treatment. Compared with the baseline, the self-care ability of patients in each group was significantly improved after treatment (P < 0.01). The PSQI data showed a significant improvement in all patients in all of the subjective PSQI items and global score (P < 0.05). Notably, ALP + BC administration had a significantly greater effect on sleep latency, quality, disturbance, and efficiency, as well as daytime dysfunction and global PSQI than the use of ALP or BC alone (P < 0.05). The PSG data showed that ALP significantly improved the sleep efficiency and decreased the arousal times, rapid eye movement (REM) sleep, and sleep latency (P < 0.05), while BC significantly improved the sleep efficiency, total sleep time, and the duration of N3 (P < 0.05). Strikingly, ALP + BC achieved the effect of both ALP and BC (P < 0.05). Importantly, the effect of the combination of ALP and BC was greater than the use of ALP or BC alone, which was consistent with the result of PSQI. In conclusion, the sleep quality and self-care ability of patients with PSI were improved by ALP and BC, thereby supporting the potential advantages of ALP combined with BC in the treatment of patients with PSI.
Highlights
Stroke is the second most common cause of deaths worldwide [1] as well as the leading cause of longterm disability [2, 3]
No significant difference was observed in the baseline characteristics of age, sex, blood glucose, triglyceride (TG), cholesterol (TC), High-density lipoprotein cholesterol (HDL-C), Low-density lipoprotein cholesterol (LDL-C), serum uric acid, and homocysteine between the three groups (P > 0.05, Table 1)
The present study examined the therapeutic effect of ALP, BC, and the combined effect of ALP and BC on improving the sleep quality and self-care ability in patients with post-stroke insomnia (PSI)
Summary
Stroke is the second most common cause of deaths worldwide [1] as well as the leading cause of longterm disability [2, 3]. Post-stroke insomnia (PSI) is a common symptom but often underestimated and is even ignored in the diagnosis and treatment [4]. PSI affects the Alprazolam and Bailemian Improve Sleep Quality functional recovery of the nervous system, aggravates the existing diseases such as hypertension and diabetes, and deteriorates the quality of life [6]. Accumulating evidence demonstrated that poor quality of sleep could be detrimental to the immune system [7], delay the recovery [8], increase pain sensitivity [9], lead to depression and anxiety [10], and affect the functional well-being [11]. The consequences of PSI and the potential clinical impact are severe, the condition is not well treated
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