Abstract
An 8-year old boy, affected by severe aplastic anemia, developed a probable pulmonary invasive aspergillosis (IA) early after a second unrelated allogeneic hematopoietic stem cell transplant (HSCT). He was treated promptly with the combination of liposomal amphotericin B and caspofungin. Despite the initial stabilization, the patient deteriorated and the antifungal therapy was switched to voriconazole and caspofungin. The patient gradually improved and was discharged home on day +29 post-HSCT on oral voriconazole. On day +119, a sudden episode of hemoptysis occurred and a right superior lobectomy was decided to remove the residual aspergilloma. The patient is now alive and well more than 24 months from HSCT. This case demonstrated that antifungal combination therapy and surgery are valid options to cure pulmonary IA even in patients at high-risk and severely immunosuppressed.
Highlights
Contributions: SC, MP, EC, CM, patient management; PG, surgery; RA, histological examination; TT, the CT examinations assessment and review; Case Report
Nly Abstract e o An 8-year old boy, affected by severe aplastic s anemia, developed a probable pulmonary invasive aspergillosis (IA) early after a second u unrelated allogeneic hematopoietic stem cell l transplant (HSCT). He was treated promptly ia with the combination of liposomal amphotericin B and caspofungin
Despite the initial rc stabilization, the patient deteriorated and the antifungal therapy was switched to voriconae zole and caspofungin
Summary
Contributions: SC, MP, EC, CM, patient management; PG, surgery; RA, histological examination; TT, the CT examinations assessment and review; Case Report. Nly Abstract e o An 8-year old boy, affected by severe aplastic s anemia, developed a probable pulmonary invasive aspergillosis (IA) early after a second u unrelated allogeneic hematopoietic stem cell l transplant (HSCT).
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