Combigraft versus Bio‐Oss/Bio‐Gide in alveolar ridge preservation: A prospective randomized controlled trial

Abstract

AbstractThe aim of this prospective study was to compare Combigraft with Bio‐Oss/Bio‐Gide complex in alveolar bone preservation in terms of clinical, laboratory and radiographic outcomes in a randomised controlled trial. 80 patients undergoing tooth extraction with the requirement of alveolar bone preservation were randomly allocated to the experimental and control groups. A total of 75 patients completed the study; 37 in the experimental group and 38 in the control group. Two patients who did not fully complete the study but had at least one record on the follow‐up period were analysed, significantly, 73 teeth among 77 dental sites were mandibular third molars which accounted for 94.8% of all subjects in this study. Bone grafting was performed using either of Combigraft or Bio‐Oss/Bio‐Gide complex. The primary outcome was to compare the height and width of alveolar ridge between immediate postoperation and six months postoperation by radiographic evaluation. A two‐sample t‐test was used for independent samples for quantitative variables (such as age) and a chi‐square statistic was used for nominal parameters. Six months after surgery, the height and width of alveolar ridge were 9.47 ± 1.61 mm and 14.71 ± 1.99 mm respectively using Combigraft while those were 9.82 ± 2.04 mm and 14.83 ± 2.04 mm respectively in the control group. There was no significant difference in the total effective rate between the two groups. Combigraft appears to be an alternative option to Bio‐Oss/Bio‐Gide complex for bone preservation in further clinical treatment. (No: CHiCTR19000230651).