Abstract
This literature review presents data on the neurobiological basis of posttraumatic disorders, which are an important problem in current psychiatry. Most attention is focused on the evolution of the concepts of combat- related post-traumatic disorders – from psychogenic to biopsychosocial. Data are presented showing that mental pathology provoked by extraordinary stress involves a wide spectrum of biological changes determining the features of the corresponding psychopathological phenomena. Results from neuroimaging, neuroendocrine, biochemical, and immunological studies of post-traumatic stress disorder are discussed. The data presented in this review widen existing concepts of the genesis of post-traumatic stress disorders, which may be relevant for improving approaches to caring for those suffering from severe stress.
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