Abstract
Columnar cell lesions of the breast represent a spectrum of alterations that have in common the presence of columnar epithelial cells lining variably dilated terminal duct lobular units, ranging from those that show little or no cytologic or architectural atypia to those that show sufficient cytologic and architectural features, to warrant a diagnosis of atypical ductal hyperplasia or ductal carcinoma in situ. These lesions are being encountered with increasing frequency in breast biopsies performed because of the presence of mammographic microcalcifications. This article reviews the diagnostic features and current understanding of the clinical significance of these lesions.
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