Coloured noise induces phenotypic diversity with energy dissipation

Abstract

Genes integrate many different sources of noise to adapt their survival strategy with energy costs, but how this noise impacts gene phenotype switching is not fully understood. Here, we refine a mechanistic model with multiplicative and additive coloured noise and analyse the influence of noise strength (NS) and autocorrelation time (AT) on gene phenotypic diversity. Different from white noise, we found that in the autocorrelation time-scale plane, increasing the multiplicative noise will broaden the bimodal region of the gene product, and additive noise will induce bimodal region drift from the lower level to the higher level, while the AT will promote this transition. Specifically, the effect of AT on gene expression is similar to a feedback loop; that is, the AT of multiplicative noise will elongate the mean first passage time (MFPT) from the low stable state to the high stable state, but it will reduce the MFPT from the high stable state to the low stable state, and the opposite is true for additive noise. Moreover, these transitions will violate the detailed equilibrium and then consume energy. By effective topology network reconstruction, we found that when the NS is small, the more obvious the bimodality is, the lower the energy dissipation; however, when the NS is large, it will consume more energy with a tendency for bimodality. The overall analysis implies that living organisms will utilize noise strength and its autocorrelation time for better survival in complex and fluctuating environments.