Abstract
AbstractThe value of colour vision assessment in the understanding of ophthalmological and neurological disorders impairments cannot be underestimated. Here we discuss impairment of parallel retinocortical pathways in early stages of Parkinson's disease. The debate on the relative contribution of retinal vs. cortical mechanisms is also addressed concerning Multiple Sclerosis and Alzheimer's Disease.We discuss evidence on the hypothesis that the retina mirrors the brain in terms of pathology and in which neurological conditions this might apply. The converse situation of retrograde degeneration in the case of multiple sclerosis is also addressed.Cortical changes secondary to retinal disease, such as glaucoma and diabetic retinopathy may also bias colour perception. Finally, we discuss the potential role of colour vision measures as disease related biomarkers that can be used for diagnostic, prognostic and treatment effects assessment.
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