Abstract
BackgroundThis study examined the effects of bovine colostrum on exercise –induced modulation of antioxidant parameters in skeletal muscle in mice. Adult male BALB/c mice were randomly divided into four groups (control, colostrum alone, exercise and exercise with colostrum) and each group had three subgroups (day 0, 21 and 42). Colostrum groups of mice were given a daily oral supplement of 50 mg/kg body weight of bovine colostrum and the exercise group of mice were made to exercise on the treadmill for 30 minutes per day. Total antioxidants, lipid hydroperoxides, xanthine oxidase and super oxide dismutase level was assayed from the homogenate of hind limb skeletal muscle.ResultsExercise—induced a significant oxidative stress in skeletal muscles as evidenced by the elevated lipid hydroperoxides and xanthine oxidase levels. There was a significant decrease in skeletal muscle total antioxidants and superoxide dismutase levels. Daily colostrum supplement significantly reduced the lipid hydroperoxides and xanthine oxidase enzyme level and increased the total antioxidant levels in the leg muscle.ConclusionThus, the findings of this study showed that daily bovine colostrum supplementation was beneficial to skeletal muscle to reduce the oxidant-induced damage during muscular exercise.
Highlights
This study examined the effects of bovine colostrum on exercise –induced modulation of antioxidant parameters in skeletal muscle in mice
The results of the present study showed that there was a main effect of time and significant impact on antioxidant levels including, lipid peroxidation [LPO], superoxide dismutases [SODs], xanthine oxidase [XO] and total antioxidant [TO], all of which indicate a positive influence following colostrum supplementation
Our results showed that there was severe oxidative stress after exercise in mice which was supported by an increased level of lipid hydroperoxides and xanthine oxidase and a reduced total antioxidants and superoxide dismutase
Summary
This study examined the effects of bovine colostrum on exercise –induced modulation of antioxidant parameters in skeletal muscle in mice. Colostrum groups of mice were given a daily oral supplement of 50 mg/kg body weight of bovine colostrum and the exercise group of mice were made to exercise on the treadmill for 30 minutes per day. One of the earliest studies that investigated the effect of BC supplementation on sporting performance in humans showed that eight days of low-dose BC supplementation during speed and strength training did not have any effect on vertical jump or recovery from exercise [9]. Later studies have shown that eight-weeks of BC supplementation of 20 g per day during endurance and resistance training significantly increased lean body mass, but no effect was observed on bench press performance [10]; while daily supplementation of 60 g BC per day for eight-weeks significantly improved sprint ability and indicated a trend towards improved vertical jump test performance [11]
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