Abstract
A simple, sensitive and accurate colorimetric estimation method was developed for the assay of Nebivolol hydrochloride in pure drug and tablet dosage form. The yellowish-orange coloured chromogen so produced was measured at 392nm for Nebivolol hydrochloride. It obeyed beer's law at the concentrations of 4–36μg/ml with coefficient of correlation (r2) of 0.999. Limit of detection (LOD) was found to be 2.558μg/ml and Limit of quantitation (LOQ) was found to be 3.764μg/ml. Validation of the method yielded good results concerning range, linearity, precision, accuracy, robustness and ruggedness. The excipients found in the formulation did not hamper the method.
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