Abstract
Sulfamethazine (SMZ) is one of the most used broad-spectrum antibiotics owing to its low cost and high efficacy towards bacterial diseases. This workreportsa novel label-free SMZ sensor based on para-sulfonatocalix[4]arene (pSC4) capped gold nanoparticles (pSC4-AuNPs) for colorimetric detection through the host-guest interaction. The existence of SMZ resulted in the aggregation of pSC4-AuNPs and canbe observed through colorimetric assay. A good linear relationship in the range 2.5 ~ 20nM was obtained with a correlation coefficient of 0.9908. The limit of detection for SMZ was 1.39nM. High recoveries (90.18-107.06%) were obtained, and RSD ranged from 1.21 to 2.05%. The color changes can be observed from red to gray within 10min. Combining the supermolecule's recognition and AuNP's optical performance, the method paves a new, easy, and rapid way for small target sensing.
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