Abstract
Oxytetracycline-capped gold nanoparticles (OTC-Au NPs) were prepared using sodium borohydride as the reductant and OTC as the capping agent, respectively. The prepared OTC-Au NPs with a size of 6nm have a maximum surface plasma resonance (SPR) absorption located at 514nm. The OTC on the surface of Au NPs still can coordinate with Eu3+ ions. Due to the property that OTC has multivalent binding sites with Eu3+ ions, Eu3+ ions can induce the aggregation of OTC-Au NPs. Based on the Eu3+ ions-aggregated OTC-Au NPs, a simple aptamer-free colorimetric sensing method for TCs was developed. Briefly, free TCs compete with OTC on the surface of Au NPs resulting in the change of OTC-Au NPs from an aggregation state to a dispersed state. The whole process takes only 5min, and as low as 20nM OTC, 14nM tetracycline (TC), and 20nM doxycycline (DC) could be sensitively detected, respectively. The proposed method was also featured as good repeatability and specificity, and was applied to the detection of OTC in lake water with satisfactory recovery.
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