Colored Polymeric Nanofiber Loaded with Minoxidil Sulphate as Beauty Coverage and Restoring Hair Loss

Fadilah Sfouq Aleanizy,Fulwah Yahya Alqahtani,Bushra Alquadeib,Esraa K Eltayeb,Hosam G Abdelhady,Ibrahim A Alsarra,Hamad M Alkahtani,Amal Aldarwesh

doi:10.1038/s41598-020-60863-0

Fadilah Sfouq Aleanizy, Fulwah Yahya Alqahtani + Show 6 more

Open Access

https://doi.org/10.1038/s41598-020-60863-0

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Abstract

Polymeric nanofibers fabricated by electrospinning either blank (PVA) or loaded with minoxidil sulphate have yielded optimum fibers with an average diameter 273 nm, and 511 nm, respectively. Thermal analysis of nanofibers indicated no chemical interaction. The NMR spectrum confirmed stability of nanofiber as there were no interactions between functional groups. Prepared nanofibers showed a 47.4% encapsulation efficiency and 73% yield. In vitro drug release of minoxidil sulphate from nanofiber exhibited an initial burst release followed by a slower release pattern. Stability studies revealed that minoxidil nanofiber was stable if stored at room temperature and protected from light with only loss of 9.6% of its nominal concentration within 6 months. As a result, the prepared solid/colored formula serves as an ideal formulation for such instable drug in liquid formula taking the advantage of the attractiveness of beauty colored coverage, and the simple, and non-tousled application.

Highlights

Electrospund nanofibers is widely used in a number of applications owing to their distinctive properties, such as high surface to volume ratio, high absorbency, tunable physicomechanical properties, easy adjustment of polymeric solutions and process parameters to produce anticipated fiber morphology and mechanical properties, and broad variety of naturally occurring and synthetic polymers that can be electrospun into nanofibers[1,2,3]
Based on several previous studies, the applicability and efficacy of minoxidil sulphate in restoring hair growth in both male and female who suffer from alopecia is well established and proved
It is believed that this work will be valuable to produce solid nanoformula of easy use and inexpensive

Summary

Introduction

Electrospund nanofibers is widely used in a number of applications owing to their distinctive properties, such as high surface to volume ratio, high absorbency, tunable physicomechanical properties, easy adjustment of polymeric solutions and process parameters to produce anticipated fiber morphology and mechanical properties, and broad variety of naturally occurring and synthetic polymers that can be electrospun into nanofibers[1,2,3]. Minoxidil sulphate is a potassium channel opener, causing hyperpolarization of cell membranes It can widen the blood vessels and open the potassium channels, allowing more oxygen, blood, and nutrients to the follicles[13]. This research aims to prepare a colored nanofiber loaded with minoxidil sulphate that with constant use will help regrow hair and at the same time offers easy application of solid stable formula that will conceal the thin area during restoring hair regrowth of this area

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