Abstract
In this paper, we investigate a mathematical model for describing the growth of tumor cell under immune response, which is driven by cross-correlation between multiplicative and additive colored noises as well as the nonzero cross-correlation in between. The expression of the mean first-passage time (MFPT) is obtained by virtue of the steepest-descent approximation. It is found: (i) When the noises are negatively cross-correlated (λ 0), then the escape is slower than in the case with no correlation. Moreover, in the case of positive cross-correlation, the escape time has a maximum for a certain intensity of one of the noises, i.e., the maximum for MFPT identifies the noise enhanced stability of the cancer state. (ii) The effect of the cross-correlation time τ 3 on the MFPT is completely opposite for λ>0 and λ<0. (iii) The self-correlation times τ 1 and τ 2 of colored noises can enhance stability of the cancer state, while the immune rate β can reduce it.
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