Colorectal cancer patients with peripheral circulating tumor cells of the change and clinical significance

Abstract

Objective Explore the dynamic changes of the patients with colorectal cancer circulating tumor cells (CTCs) in judging the prognosis, adjust the application value of treatment. Methods Select 88 cases of clinically diagnosed with colorectal cancer patients for the first time, the method of the second generation of enrichment of circulating tumor cells and fluorescence imaging technique, 1 day before the surgery, 1 month after the surgery, in late June and late December four detection of CTCs in peripheral blood. Analysis of patients in different periods of whether CTCs value, histological type, lymph node metastasis. Measurement based on the end of December of CTCs values compared with January measurement of CTCs is increased, divided into higher and higher than groups, compared two groups of recurrence and survival time. Results Of 88 patients with colorectal cancer, back to the blind and litres of 18 cases of colorectal cancer, 10 cases of colorectal cancer, 20 patients with sigmoid colorectal cancer, rectalcancer 40 cases, among them, the males 47 cases, aged 51-86 years old, 41 cases were female, aged 42-88 years old. Higher in group comparison, groups: 56 cases, higher than group of 32 cases. The baseline is similar between the two groups had no statistical significance (χ2=0.002, t=0.780, P=0.950); Residency histological differentiation degree, CTCs is higher than the degree of differentiation, the difference was statistically significant (F=12.28, P=0.001); In patients with lymph node metastasis of CTCs is higher than without metastasis, the difference was statistically significant (F=57.37, P=0.001); Increased survival time less than the higher group, (χ2=10.665, P=0.001), increased cases of recurrence is higher than the group (χ2=5.684, P=0.017), the difference had statistical significance. Conclusion Monitoring CTCs value dynamic changes of tumor recurrence in patients with colorectal cancer early judgment of judgment, the curative effect of postoperative chemotherapy, surgery, and postoperative recurrence in the short term of patients with stage Ⅱ and Ⅲ colorectal cancer and the treatment of patients with stage IV has guiding significance to the plan selection and improvement. Key words: Circulating tumor cells; Colorectal cancer; Prognosis