Colorectal cancer in Iran: Molecular epidemiology and screening strategies.

Roya Dolatkhah,Saeed Dastgiri,Mohammad hossein Somi,Iraj Asvadi Kermani,Morteza Jabbarpour Bonyadi,Faris Farassati

doi:10.1200/jco.2015.33.15_suppl.e12513

Abstract

e12513 Background: The increasing incidence of colorectal cancer (CRC) in the past three decades in Iran has made it a major public health burden. This study aimed to report its epidemiologic features, molecular genetic aspects, survival, heredity and screening pattern in Iran. Methods: A comprehensive literature review was conducted to identify the relevant published articles. We used medical subject headings, including: colorectal cancer, molecular genetics, KRAS and BRAF mutations, screening, survival, epidemiologic study, and Iran. Results: Age Standardized Incidence Rate of Iranian CRCs was 11.6 and 10.5 for men and women, respectively. Overall five-year survival rate was 41%, and the proportion of CRC among the younger age group was higher than that of western countries. Depending on ethnicity, geographical region, dietary and genetic predisposition, mutation genes were considerably diverse and distinct among CRCs across Iran. The high occurrence of CRC in records of relatives of CRC patients showed...

Highlights

Introduction and BackgroundCancer is a major health problem worldwide and imposes a great economic and psychological burden in addition to loss of life and fertility
This review study was conducted to document the epidemiologic features of Colorectal cancer (CRC) in Iran: age standardized incidence, survival rates, prognostic factors, burden of disease, heredity pattern, occurrence of sporadic cases in relatives, and so forth
Similar to other screening programs, the strategy for screening for CRC should be assessed with respect to its effectiveness, sensitivity, the number of false positive results, safety, and comfort

Summary

Introduction

Introduction and BackgroundCancer is a major health problem worldwide and imposes a great economic and psychological burden in addition to loss of life and fertility. Colorectal cancer (CRC) is one of the most common types of cancer affecting 1.23 million individuals per year (9.7% of overall cancers) and is the fourth most common cause of death from cancer worldwide (608,000 cases, 8% of overall cancer deaths). The incidence of CRC has been estimated to be 30–50 cases (per 100,000) in northern America and Europe and 3–7 cases (per 100,000) in most Middle East countries. Epidemiology data show a marked variability around the world, and almost 60% of cases occur in developed countries, its overall incidence rate shows a slow but steady decrease (about 2% per year) in developed countries. The proportion of CRC cases occurring among younger age group (≤40 years) is 2–8 percent in western countries where it is about 15–35 percent in the Middle East region [1,2,3]

Objectives

Methods

Results

Conclusion