Colorectal cancer in familial adenomatous polyposis: Are there clinical predictive factors?

Abstract

BackgroundFamilial Adenomatous Polyposis (FAP) is a hereditary disorder with multiple colorectal polyps that exhibit an almost inevitable risk of colorectal cancer (CRC) in untreated patients. GoalsTo evaluate clinical features related to CRC risk at diagnosis. Material and methodsCharts from 88 patients were reviewed to collect information regarding age, family history, symptoms, polyposis severity and association with CRC. Results41 men (46.6%) and 47 women (53.4%) were assisted. CRC was detected in 53 patients (60.2%), with a frequency of 9.1% under 20 years, 58% between 21–40 and 85% over 41 years of age. Average age of patients without CRC was lower at treatment (29.5 vs 40.0 years; P=.001). Family history was reported by 58 patients (65.9%), whose average age did not differ from those who didn’t report it (33.4 vs 34.4; P=.17). Asymptomatic patients comprised 10.2% of the total; in this group, CRC incidence was much lower when compared to those presenting symptoms (1.1% vs 65.8%; P=.001). Patients without CRC presented a shorter length of symptoms (15.2 vs 26.4 months; P=.03) and less frequent weight loss (11.4% vs 33.9%; P=.01). At colonoscopy, polyposis was classified as attenuated in 12 patients (14.3%), who presented greater average age (48.2 vs 33.3 years; P=.02) and equal CRC incidence (58.3% vs 58.3%; P=.6) when compared to those with classic polyposis. ConclusionsThe risk of CRC in FAP patients 1) increases significantly after the second decade; 2) is associated with higher age, weight loss, presence and duration of simptomatology; 3) is similar in patients with attenuated or classic phenotype.