Abstract
Some studies have suggested that colorectal cancer at a younger age had distinct biological characteristics: different clinical presentations, more advanced stage at time of diagnosis and poorly differentiated carcinoma. The aim of the study is to analyze clinical and histopathological differences between younger (≤40 years of age) and older (>40 years of age) colorectal cancer patients. A cross-sectional analysis was conducted amongst the colorectal cancer patients who visited Bir Hospital between July 2015 and April 2017. All colonoscopically diagnosed and histopathologically proven cases of colon cancer were included. Chi-square test and independent t - test was performed to analyze the difference between clinical presentations and histopathological findings among two groups of patients and P value of <0.05 was considered as significant. Thirty younger patients and thirty older patients were enrolled without any differences in gender proportion. There were no statistical differences between clinical presentation and histological grade and type in younger and older patients. The younger patients had more complaints of altered bowel habit (P <0.001) while older patients mostly presented with per rectal bleeding (P< 0.008). In this study, colorectal cancer at younger ages showed similar characteristics to those of older patients except altered bowel habit was more common in younger patients while per rectal bleeding was more common in older patients. Although colorectal cancer incidence increases with age, younger patients with altered bowel habits, weight loss, anemia and anorexia should also be given due medical attention and undergo evaluation promptly.
Highlights
Some studies have suggested that colorectal cancer at a younger age had distinct biological characteristics: different clinical presentations, more advanced stage at time of diagnosis and poorly differentiated carcinoma
If we compare the two groups, the older group frequently complained of PR bleeding (P=0.008) while the younger group mostly complained for altered bowel habit (P
Colorectal cancer at younger ages showed similar clinical features to those of older patients except altered bowel habit was more common in younger patients while per rectal bleeding was more common in older patients which is contradiction to the study done by Nurdjanah S et al,[8] which showed hematochezia was more common in young group and altered defecation pattern were the most reported complaint in the older group
Summary
Some studies have suggested that colorectal cancer at a younger age had distinct biological characteristics: different clinical presentations, more advanced stage at time of diagnosis and poorly differentiated carcinoma. The aim of the study is to analyze clinical and histopathological differences between younger (≤40 years of age) and older (>40 years of age) colorectal cancer patients. Colorectal carcinoma (CRC) is one of the most common cancers diagnosed worldwide, with over 1.2 million new cases diagnosed each year.[1] Despite improvements in screening for early diagnosis, colorectal cancer remains one of the biggest cancer killers in the world It is documented as the fourth most frequent cancer in men and third in women.[2] It is one of the most common cancers in Nepal.[3]. CRC occurs predominantly in older people, it does affect young adults with a high incidence of up to 28% and this incidence is higher in Asia.[4]
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