Abstract
Pterostilbene is natural antioxidant phytochemical from blue berries. We have been demonstrated that pterostilbene stimulates human colon cancer cell death by endoplasmic reticulum (ER) stress, GRP78‐eIFα‐ATF3 pathway, on previous our studies. However, it is still not clear whether pterostilbene regulate Bcl‐2 family signaling pathway undergo apoptosis in colon cancer cells. In the current study, analysis of the gene expression by western blotting and RT‐PCR revealed that pterostilbene modulated the expression of Bcl‐2, Bak1, and Bax in human colon cancer cells. Our results also showed that pterostilbene triggered the expression of scavenger receptor CD36, which is one of the crucial factor cancer cells undergoing mitochondria dependent apoptosis. These observations indicate that pterostilbene as a potent natural chemotherapeutic compound and provide a part of evidence for role of Bcl‐2 family signaling pathway and scavenger receptor CD36 in mediating pterostilbene in human colon cancer cells.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.