Abstract
Pterostilbene is natural antioxidant phytochemical from blue berries. We have been demonstrated that pterostilbene stimulates human colon cancer cell death by endoplasmic reticulum (ER) stress, GRP78‐eIFα‐ATF3 pathway, on previous our studies. However, it is still not clear whether pterostilbene regulate Bcl‐2 family signaling pathway undergo apoptosis in colon cancer cells. In the current study, analysis of the gene expression by western blotting and RT‐PCR revealed that pterostilbene modulated the expression of Bcl‐2, Bak1, and Bax in human colon cancer cells. Our results also showed that pterostilbene triggered the expression of scavenger receptor CD36, which is one of the crucial factor cancer cells undergoing mitochondria dependent apoptosis. These observations indicate that pterostilbene as a potent natural chemotherapeutic compound and provide a part of evidence for role of Bcl‐2 family signaling pathway and scavenger receptor CD36 in mediating pterostilbene in human colon cancer cells.
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