Colorectal cancer and adjacent normal mucosa differ in apoptotic and inflammatory protein expression

Abstract

Colorectal cancer usually refers to the occurrence of the appendix, rectum or colon and other parts of the malignant tumor in the large intestine mucosa and glands, is also one of the most common malignant tumors in human. In recent years, studies have shown that chronic inflammation is the "initiator" of cancer. Inflammation plays a causal role in the early formation of tumors by regulating the initiation and promotion of tumor genesis and development through a series of inflammatory cytokines. Inflammation plays a causal role in the early formation of tumors by regulating the initiation and promotion of tumor genesis and development through a series of inflammatory cytokines. The latter part of this review describes the role of several important inflammatory factors: tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and transforming growth factor-β (TGF-β) in colorectal cancer. In normal mucosa, inflammatory factors play an important role in the immune response of the body. However, when a large number of inflammatory factors accumulate, they will cause pathological damage to the body, trigger inflammation and even deteriorate into cancer. Serum levels of most inflammatory factors were low in healthy controls, but were elevated in colorectal cancer patients. Here, we review the relationship between apoptosis, inflammation and cancer, and analyze the difference in the expression of inflammatory proteins in colorectal cancer and its adjacent mucosa.