Abstract
Dichromatic vision is common in many mammals. However, color processing in the primary visual cortex (V1) of dichromatic mammals is relatively unknown compared to the trichromatic primates. In this study, we investigated the functional organization of color processing in mouse V1. The mouse retina has a graded expression pattern of two opsins along its dorsoventral axis. However, it is not clear whether and how this expression pattern is reflected in the cortical representation at local (several hundred microns) and areal (V1) level. Using in vivo two-photon calcium (Ca2+) imaging and wide-field Ca2+ imaging, we revealed that V1 neurons responded to S (UV)- and M (green)-opsin isolating stimuli with slightly biased color preference depending on retinotopic position in V1. This was consistent with the distribution of retinal opsins. At the cellular level, preferences for S- and M-opsin isolating stimuli were intermingled in a local region encompassing several hundred microns. These results suggest that functional organizations of color information are locally intermingled, but slightly biased depending on the retinotopic position in mouse V1.
Highlights
Color provides important information for our lives
Simple UV light sources were used in previous studies of color processing in the mouse V1 (Ekesten and Gouras, 2008; Tan et al, 2015)
Distributions of color selective index (CSI) appeared to follow a normal distribution (Figure 2B). These results suggest that neurons in the mouse V1 have various degrees of color preference in the normal distribution manner
Summary
Except for trichromatic primates (De Valois, 1960; Wiesel and Hubel, 1966; Livingstone and Hubel, 1984; Hendry and Reid, 2000; Chatterjee and Callaway, 2003), dichromatic color vision is common (Loop et al, 1987; Neitz and Jacobs, 1989; Jacobs et al, 1991; Calderone and Jacobs, 2003). Cones express both opsins in a graded manner along the dorsoventral axis
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