Abstract
The highly sensitive interfacial effects between liquid crystal (LC) and alignment layers make LC-bioinspired sensors an important technology. However, LC-bioinspired sensors are limited by quantification requiring a polarized microscope and expensive equipment, which makes it difficult to commercialize LC-bioinspired sensors. In this report, we first demonstrate that dye-doped LC (DDLC) chips coated with vertically aligned layers can be employed as a new LC-bioinspired sensing technology. The DDLC-bioinspired sensor was tested by detecting bovine serum albumin (BSA) and immunocomplexes of BSA pairs. The intensities of the dye color of the DDLC-bioinspired sensor can be changed with the concentrations of biomolecules and immunocomplexes. A detection limit of 0.5 µg/mL was shown for the color-indicating DDLC-bioinspired sensors. We also designed a new method to use the quantitative DDLC-bioinspired sensor with a smart-phone for potential of home test. The novel DDLC-bioinspired sensor is cheap, label-free, and easy to use, furthering the technology for home and field-based disease-related detection.
Highlights
The first liquid crystal (LC)-bioinspired sensor was invented in 2001 [1]
We investigated dye-doped LC (DDLC) as a bioinspired sensing chip for quantifying certain important proteins: bovine serum albumin (BSA) and immunocomplexes formed of BSA pairs
DDLC-bioinspired wason placed on white paper, paper, effectivelyproperty
Summary
The first liquid crystal (LC)-bioinspired sensor was invented in 2001 [1]. LC-based-bioinspired sensors have since become a hot topic of research [2,3,4]. Polymers 2020, 12, 2294 sensor changes, which can be observed under cross-polarized optical microscopy (cPOM) [5]. LC-bioinspired sensors are used to detect many substances, such as cancer biomarkers, bovine serum albumin (BSA), immunoreactions, and DNA [1,3,4,6,7,8,9]. The most important is the detection of standard BSA for observation and establishing of basic characteristics [10,11,12]. The most important problem with LC-bioinspired sensors is the need for expensive equipment such as POM, electro-optical systems, and spectrometers. This makes it difficult to use LC-bioinspired sensors for home-based or clinical applications
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