Abstract
Miniaturization of imaging systems can significantly benefit clinical diagnosis in challenging environments, where access to physicians and good equipment can be limited. Sub-pixel resolving optofluidic microscope (SROFM) offers high-resolution imaging in the form of an on-chip device, with the combination of microfluidics and inexpensive CMOS image sensors. In this work, we report on the implementation of color SROFM prototypes with a demonstrated optical resolution of 0.66 µm at their highest acuity. We applied the prototypes to perform color imaging of red blood cells (RBCs) infected with Plasmodium falciparum, a particularly harmful type of malaria parasites and one of the major causes of death in the developing world.
Highlights
The optical microscope is an essential tool in biological science and medical diagnostics
We have developed a compact high-resolution color imaging microscopy device based on sub-pixel resolving optofluidic microscopy (SROFM) and color illumination
Our preliminary experiment indicates that color sub-pixel resolving optofluidic microscope (OFM) (SROFM) can potentially be a useful diagnostic tool for identifying malaria infected cells
Summary
The optical microscope is an essential tool in biological science and medical diagnostics. There has been an increased interest in the miniaturization of microscopes and various methods have been reported for the construction of low-cost, hand-held imaging devices [3,4,5,6,7,8]. Sub-pixel resolving OFM (SROFM) has been developed [7], with the incorporation of a pixel super-resolution algorithm [9,10], which further reduces the device cost and improves the yield of imaged samples. This scheme removes the need for submicron apertures, instead taking and combining a sequence of low-resolution directprojection images to reconstruct a resolution-enhanced image
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