Abstract
Recent studies on the pathophysiology of irritable bowel syndrome (IBS) have focused on the role of mast cells (MCs) in intestinal mucosal immunity. A link between allergic airway diseases (AADs) and IBS has been suggested because both diseases have similar pathophysiology. We aimed to investigate whether the induction of AAD in mice could lead to inflammation of the colonic mucosa, similar to IBS. We also evaluated whether this inflammatory response could be suppressed by administering a therapeutic agent. Mice were divided into three groups: control, AAD-induced, and salbutamol-treated. An AAD mouse model was established by intraperitoneal injection and nasal challenge with ovalbumin. Mice with AAD were intranasally administered salbutamol. Analyses of cytokine levels, MC count, and tryptase levels in the intestinal mucosa were performed to compare the changes in inflammatory responses among the three groups. Inflammation was observed in the intestinal mucosa of mice in the AAD group. This inflammation in AAD mice was suppressed after salbutamol treatment. Our study demonstrates that AAD induces an inflammatory response similar to that in IBS, suggesting a possible association between IBS and AADs. In patients with IBS with such allergic components, salbutamol may have the potential to alleviate the inflammatory response.
Highlights
Irritable bowel syndrome (IBS) is a gastrointestinal disorder that manifests as recurrent abdominal pain associated with bowel movements or changes in bowel habits [1]
Recent studies on the pathophysiology of IBS have focused on the role of mast cells (MCs) in mediating intestinal mucosal immunity and low-grade inflammation [3,4]
Allergic airway diseases (AADs), such as allergic rhinitis (AR) or asthma, are type I hypersensitivity reactions caused by the release of mediators from MCs
Summary
Irritable bowel syndrome (IBS) is a gastrointestinal disorder that manifests as recurrent abdominal pain associated with bowel movements or changes in bowel habits [1]. IBS is commonly diagnosed worldwide and has an estimated prevalence of 10–15%; its pathophysiology has not yet been accurately identified [2]. IBS was previously considered a psychosomatic or functional disease, it is considered a heterogeneous group of conditions with various subsets. Among various diseases may cause IBS, it has been suggested that allergic diseases may be linked to IBS. Recent studies on the pathophysiology of IBS have focused on the role of mast cells (MCs) in mediating intestinal mucosal immunity and low-grade inflammation [3,4]. Allergic airway diseases (AADs), such as allergic rhinitis (AR) or asthma, are type I hypersensitivity reactions caused by the release of mediators from MCs. It has been suggested that AADs may be linked to IBS, as both diseases share a similar pathophysiology and result from
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