Abstract
BackgroundExtra-gastric (particularly colonic) lymphoma of mucosa-associated lymphoid tissue in the immunosuppressed solid organ transplant recipient is rare. We report a case of low-volume mucosa-associated lymphoid tissue lymphoma with colonic and bone marrow involvement in a renal transplant recipient that has been managed conservatively.Case presentationA 62-year-old Caucasian man, 14 years after kidney transplantation, was diagnosed as having extra-nodal marginal zone lymphoma of mucosa-associated lymphoid tissue with bone marrow and colonic involvement, after a colonoscopy identified mucosa-associated lymphoid tissue lymphoma in a sessile sigmoid polyp following surveillance fecal occult blood testing that returned a positive result. A gastric biopsy showed no evidence of Helicobacter pylori, but Helicobacter pylori immunoglobulin G was positive. He received Helicobacter pylori eradication treatment and is being managed expectantly. Immunosuppression was unchanged with prednisolone, mycophenolate mofetil, and cyclosporine A. Renal allograft function has remained stable.ConclusionsThis case highlights the unexpected occurrence of colonic mucosa-associated lymphoid tissue lymphoma in a kidney transplant recipient. The case emphasizes the importance of histopathological diagnosis of colonic lesions in this patient cohort because the unusual diagnosis of low-volume mucosa-associated lymphoid tissue lymphoma can be managed expectantly as it does not appear to be clinically aggressive in the immunosuppressed solid organ transplant.
Highlights
Extra-gastric lymphoma of mucosa-associated lymphoid tissue in the immunosuppressed solid organ transplant recipient is rare
We report a case of a renal transplant recipient with an unexpected diagnosis of Mucosa-associated lymphoid tissue (MALT) lymphoma with colonic and bone marrow involvement; the diagnosis was made
Case presentation This report describes an asymptomatic 62-year-old Caucasian man with a deceased-donor kidney transplant for end-stage kidney disease for obstructive uropathy due to renal calculi from childhood, 14 years posttransplantation, who was diagnosed as having extranodal marginal zone MALT lymphoma with bone marrow and colonic involvement; the diagnosis was made after a positive occult blood testing, which was conducted as part of routine cancer screening post-renal transplantation
Summary
This case of unexpected colonic MALT lymphoma highlights the importance of judicious cancer screening with histopathological diagnosis of suspicious colonic lesions in immunosuppressed solid organ transplant recipients.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
