Colon Targeting Using pH Sensitive Materials

Ashish Jain

doi:10.19080/argh.2018.08.555748

Abstract

Colon Targeting Using pH Sensitive Materials

Highlights

To supply a therapeutic amount of drug to a target site in a body is the major goal of any conventional or novel drug delivery system
The colon specific drug delivery system should be capable of protecting the drug till itgets released to the colon i.e. drug release and absorption should not occur in the stomach and the small intestine, Thecolonissupposedtobeasuitableabsorption sitefordrugsbecauseoflack of digestive enzymes, relatively proteolytic activity of colon mucosa is much less in compare to the small intestine which leads to greater systemic bioavailability, and a long residence time up to 24 hour [1]
Colon specific delivery of drugs is of interest for the treatment of colonic diseases, so as to maximize the effectiveness of these drugs

Summary

Ashish Jain*

Submission: December 13, 2017; Published: February 02, 2018 *Corresponding author: Ashish Jain, Department of Pharmaceutical Sciences, Dr Hari Singh Gour Vishwavidyalaya, Sagar, Mandhya Pradhesh - 470 003, India, Tel: +91 9407551498, E-mail: Abstract. The oral route is the preferred route for drug delivery, among oral delivery Intestine and colon drug delivery have been used for molecules aimed at local treatment of colonic diseases such as Colon Cancer, Polyp, Colorectal, Crohn’s Disease, Inflammatory Bowel Disease (IBD), Ulcerative Colitis (UC) etc. For delivery of molecules susceptible to enzymatic degradation such as peptides. There are various methods have been reported for colon targeting, among them use of pH sensitive polymers for coating and formulation of drug delivery system is most beneficial. The formulations of pH sensitive nanoparticles, hydrogel, microspheres, Polymeric Micelles are commonly reported for colon targeting. This review focuses on advancements of pH sensitive drug delivery system for colon targeting

Introduction

Approaches for targeting drugs into the colon

Rectum Anal canal

Polymeric micelles

Conclusion

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