Abstract
The colon is a site where both local and systemic delivery of drugs can take place. The colon targeted drug delivery system is used for the treatment of various diseases related to colon like Crohn’s disease, ulcerative colitis, etc and systemic delivery of therapeutic peptides and proteins. It can be possible to target disease site thus lowers the requirement of higher doses of drug and reducing the dosage frequency and cost of the drugs. It also lowers the systemic side effects. For successful colon targeted drug delivery, a drug needs to be protected from degradation, release and absorption in the upper portion of the gastric intestinal tract and then to be ensured abrupt or controlled release in the proximal colon. This article gives detail description on anatomy and physiology of the colon and approaches utilized for colon specific drug delivery like prodrugs, pH and time dependent, prodrug, osmotic pressure controlled drug delivery. Peer Review History: Received 19 August; Revised 28 August; Accepted 5 September, Available online 15 September 2017 UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main of purpose it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency. Received file: Reviewer's Comments: Average Peer review marks at initial stage: 4.5/10 Average Peer review marks at publication stage: 7.0/10 Reviewer(s) detail: Prof. Dr. Syamsudin Abdillah, Pancasila University, Indonesia, syamsudin.abdillah@gmail.com Dr. Masoomeh S Ghahfarokhi, University of Benin, Nigeria, mshamsgh@yahoo.com Similar Articles: DEVELOPMENT AND EVALUATION OF ALBENDAZOLE MICROCAPSULE FOR COLONIC DRUG DELIVERY SYSTEM FORMULATION AND EVALUATION OF COLON TARGETED MATRIX TABLETS CONTAINING EXTRACT OF SOLENOSTEMMA ARGEL (HARGEL)
Highlights
The colon is a site where both local and systemic delivery of drugs can take place
Glycosides are hydrophilic and poorly absorb from GIT because of this properties it use as the carrier for delivering drug to colon
Dissolution tests of a colon-specific formulation in various media simulating pH conditions and times likely to be encountered at various locations in the gastrointestinal tract The different media that are used for the dissolution testing of colon targeted drug delivery are pH 1.2 to simulate gastric fluid, pH 6.8 to simulate small intestine, pH 7.4 to simulate large intestine
Summary
Since the past decades research is going on in developing the methods to deliver therapeutic amount of drug to the specific organ so that the desired concentration can be achieved swiftly and maintained[1]. Colon targeted drug delivery is used to deliver the substances that are polar and degraded by the digestive enzymes in the gastrointestinal tract. Proteins and peptides such as insulin, calcitonin and vasopressin, cytokine inhibitors and antibiotics may be delivered systematically via colonic absorption. Antiasthmatic drugs, antihypertensive drugs and antidiabetic agents can be delivered systemically[2] It is used for the treatment of various diseases like ulcerative colitis, Crohn’s disease, intestinal cancer, diarrhea, for the treatment of diseases sensitive to circadian rhythms like asthma, angina, for the delivery of steroids, etc[3]. Increase bioavailability of poorly absorbable drugs[8]
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