Coloclyster of Red Peony Root Granules Alleviates Moderately Severe Acute Pancreatitis: A Double-Blinded, Placebo-Controlled, Randomized Clinical Trial.

Fangyong Yang,Meitang Wang,Xiaoqiang Yue,Haitao Huang,Yiqi Du,Yan Chen,Lina Wang,Xiuzhong Qi,Dezeng Zhu

doi:10.1155/2020/8401239

Abstract

The red peony root derived from Paeonia lactiflora has been applied to treat human inflammatory diseases. To investigate its therapeutic potential in treating moderately severe acute pancreatitis (MSAP), which has been rarely studied, this study was designed as a double-blinded, placebo-controlled, randomized clinical trial. A total of 60 MSAP patients were enrolled and randomly divided into an experimental (n = 30) group and a control group (n = 30), who received a coloclyster of 15 g of red peony root or placebo granules dissolved in 150 mL of water, respectively. The patients' demographic and clinical characteristics were recorded. The results showed that the experimental group had a shorter remission time of fever (p < 0.05) and abdominal pain (p < 0.01) and faster resumption of self-defecation (p < 0.01) than did the control group. In addition, the coloclyster of red peony root decreased the modified Balthazar CT score as well as the serum interleukin-6 and tumor necrosis factor-alpha levels to a greater extent than did the placebo coloclyster (p < 0.05). The remission times for the normalization of white blood cells and percentage of neutrophils and lymphocytes in the experimental group were also significantly shorter than those in the control group (p < 0.05). In conclusion, a coloclyster of red peony root could help alleviate the clinical symptoms and shorten the course of MSAP by possibly attenuating systematic inflammation. This trial is registered with 14004664.

Highlights

Acute pancreatitis (AP) is one of the most common causes of acute abdominal pain in clinical practice, which is characterized by inflammation and autodigestion of the pancreas [1]
Identification of the Red Peony Root. e probable chemical constituents of the red peony root were collected according to the related literature that previously reported the constituents in the red peony root and related species
Patients with AP may progress rapidly into septic shock, which is associated with a very poor outcome. us, the development of effective treatments for AP is vital to the improvement of the clinical outcome in such patients

Summary

Introduction

Acute pancreatitis (AP) is one of the most common causes of acute abdominal pain in clinical practice, which is characterized by inflammation and autodigestion of the pancreas [1]. In-hospital mortality rate of patients with severe acute pancreatitis (SAP) are estimated to be 5%–42% [3,4,5,6]. Patients with SAP usually present with fever, abdominal pain, subcutaneous bleeding, Evidence-Based Complementary and Alternative Medicine sepsis, and sometimes systematic inflammatory response syndrome and multiple organ dysfunction syndrome. The therapeutic potential of multidisciplinary treatment of SAP has been widely acknowledged and recommended [7], especially the introduction of traditional Chinese medicine. A great deal of evidence has demonstrated that a variety of traditional Chinese herbs exhibit anti-inflammatory activity [8, 9]; in particular, the red peony root derived from Paeonialactiflor is expected to be of special clinical significance in the treatment of SAP

Methods

Results

Conclusion